"With Full Intent" is based on the true events of a brutal quadruple murder that shook Southside Virginia on the eve of April Fool’s Day, 1933. Two elderly brothers and their nephews were mercilessly slain and robbed at their plantation, their bodies discovered by a Black farmhand the following morning. The investigation that followed was marred by racial bias and procedural failures, as local and state investigators allowed critical evidence to be compromised.

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Enter Deputy Kendricks, a forward-thinking officer determined to apply modern investigative techniques amidst the era's prevailing prejudices and ineptitude. As Kendricks navigates through a compromised case, further complicated by the murder of a key witness across state lines, he faces personal challenges, including a romantic entanglement with the sister of a prime suspect. Through perseverance and an unwavering commitment to justice, Kendricks strives to overcome external and internal obstacles to bring the killers to justice.